Human CD30, His Tag, HEK293

Catalog Number

LDG041PHM

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression System

    HEK293

  • Affinity Tag

    His Tag (C-term)

    Storage Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 39.25 kDa.
    The protein migrates as 55-75 kDa under reducing condition (SDS-PAGE analysis).

  • Endotoxin Level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Form

    Lyophilized

• Background

  • Background

    Human CD30, also known as TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily Member 8), is a cell surface glycoprotein belonging to the tumor necrosis factor receptor (TNFR) superfamily. It is primarily expressed on activated T and B lymphocytes and plays a crucial role in immune regulation and inflammation. CD30 activation triggers signaling pathways involved in cell proliferation, survival, and cytokine production, contributing to the modulation of immune responses. Aberrant CD30 expression is associated with various lymphoproliferative disorders, including Hodgkin's lymphoma, anaplastic large cell lymphoma, and other malignancies. Therapeutically, CD30 has emerged as a promising target for antibody-based immunotherapy, such as antibody-drug conjugates, which selectively deliver cytotoxic agents to CD30-expressing tumor cells, demonstrating efficacy in the treatment of CD30-positive malignancies. Understanding the multifaceted roles of CD30 in immune regulation and disease pathogenesis holds significance for the development of targeted therapies and precision medicine approaches in oncology and immunology.

    Synonyms

    Tumor necrosis factor receptor superfamily member 8 (TNFRSF8), CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, CD30

  • Sequence Note

    Met1-Lys379

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in 4 mM HCl to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant human CD30.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.