Human DR5, His Tag, E. coli

Catalog Number

LDG190PHE

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression System

    Escherichia coli

  • Affinity Tag

    His Tag (C-term)

    Storage Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 8.0.

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 15.2 kDa.

  • Endotoxin Level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Form

    Lyophilized

• Background

  • Background

    DR5 (Death Receptor 5), also known as CD262 or TRAIL-R2 (Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2), is a cell surface receptor belonging to the tumor necrosis factor receptor superfamily. It plays a crucial role in apoptosis, or programmed cell death, by binding to its ligand, TRAIL (Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand). Upon ligand binding, CD262 triggers apoptotic signaling cascades within the cell, leading to cell death. CD262-mediated apoptosis is an important mechanism for regulating cell proliferation and maintaining tissue homeostasis. Additionally, CD262 activation has been explored for its therapeutic potential in cancer treatment, as it selectively induces apoptosis in cancer cells while sparing normal cells. Understanding the function and regulation of CD262 is essential for developing targeted therapies for cancer and other diseases.

    Synonyms

    Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL receptor 2; TRAIL-R2), CD262

  • Sequence Note

    Met1-Glu182

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant human DR5.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.