Mouse PD-L2, His Tag, CHO

Catalog Number

LDG013PMM

Datasheet

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• Specifications

  • Species of Origin

    Mouse

    Expression System

    CHO

  • Affinity Tag

    His Tag (C-term)

    Storage Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 23.35 kDa.
    The protein migrates as 30-40 kDa under reducing condition (SDS-PAGE analysis).

  • Endotoxin Level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Mycoplasma

    Not detected

  • Form

    Lyophilized

• Background

  • Background

    PD-L2, or Programmed Death-Ligand 2, is a transmembrane protein expressed on antigen-presenting cells and non-hematopoietic cells. It functions as a ligand for the programmed cell death protein 1 (PD-1) receptor on T cells, delivering inhibitory signals that regulate immune responses. PD-L2 engagement with PD-1 contributes to T cell exhaustion, immune tolerance, and evasion of immune surveillance by tumors. Blockade of the PD-L2/PD-1 pathway has emerged as a promising strategy in cancer immunotherapy, enhancing anti-tumor immune responses. Understanding PD-L2's role in immune regulation is essential for developing targeted therapies for cancer and autoimmune diseases.

    Synonyms

    PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC (B7-DC), CD273

  • Uniprot ID

    NP_067371

    Sequence Note

    Met1-Arg219

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 0.2 mg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant mouse PD-L2.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.