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Leadgene Leadgene

Renal disease animal models are designed to replicate the pathogenesis, progression, and treatment response of human kidney diseases. These models are widely used in research on chronic kidney disease (CKD), acute kidney injury (AKI), diabetic kidney disease (DKD), and nephritis.

They are essential for evaluating the efficacy of renal disease treatments, regenerative medicine approaches, and kidney replacement therapies.

 

SIDSCO Biomedical Co., Ltd., a subsidiary of Leadgene Biomedical, is a TAF-certified and GLP-compliant laboratory authorized to conduct toxicity testing for pharmaceuticals, health foods, and regenerative medicine products.

 

SIDSCO Biomedical specializes in developing renal disease animal models using the following approaches:

 Renal Disease Animal Model

Disease type

Method

Application

Unilateral Ureteral Obstruction (UUO) Model

Tubulointerstitial fibrosis

Induction of fibrosis through unilateral ureteral obstruction

Used to study the pathological mechanisms of chronic kidney disease and evaluate anti-fibrotic therapies.

5/6 Nephrectomy Model

Chronic kidney disease

5/6 nephrectomy (removal of 5/6 of total kidney mass)

Used to investigate renal fibrosis, end-stage renal disease (ESRD), and kidney compensatory mechanisms.

 

 

 

 

 

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