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Leadgene Leadgene

Pulmonary disease animal models are essential for replicating the pathological mechanisms of human lung diseases, facilitating the study of disease progression, evaluation of novel therapies, and assessment of drug efficacy.

These models are widely applied in research on chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, asthma, lung infections, and acute respiratory distress syndrome (ARDS).

 

SIDSCO Biomedical Co., Ltd., a subsidiary of Leadgene Biomedical, is a TAF-certified and GLP-compliant laboratory authorized to conduct toxicity testing for pharmaceuticals, health foods, and regenerative medicine products.

 

 

SIDSCO Biomedical develops pulmonary disease models using the following approaches:

Pulmonary Disease Animal Model

Disease type

Method

Application

Pulmonary Fibrosis Model (Bleomycin-Induced Pulmonary Fibrosis)

Pulmonary inflammation and fibrosis

Tracheal instillation of bleomycin

Used to evaluate anti-fibrotic therapies, including TGF-β inhibitors and antioxidant treatments.

Bacterial Pneumonia Model (Lipopolysaccharide-Induced Pulmonary Inflammation)

Acute lung injury and pulmonary inflammation

Tracheal instillation of lipopolysaccharide (LPS)

Used to investigate the pathogenesis of allergic asthma and to evaluate anti-allergic and anti-inflammatory drugs, such as IL-4, IL-5, and IL-13 inhibitors.

 

 

 

 

 

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