Canine CTLA-4 Protein, His Tag, HEK293

Catalog Number

LDG004POM

Datasheet

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• Overview

  Description

  CTLA-4 is a protein belonging to the immunoglobulin superfamily and the CD28 receptor family. It interacts with CD80 (B7-1) and CD86 (B7-2) to transmit inhibitory signals to T cells, in contrast to CD28, which sends stimulatory signals. This receptor is also found within regulatory T cells, where it plays a vital role in their functions. CTLA-4 is a key regulator of T cell activation, making it an appealing candidate for autoimmune disease therapy and cancer immunotherapy. Recent evidence further highlights its importance in the function and balance of regulatory T cells (Treg).

• Specifications

  • Species of Origin

    Canine

    Expression system

    HEK293

  • Affinity Tag

    His Tag (C-term)

    Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >90% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 14 kDa.
    The protein migrates as 18-23 kDa uder reducing condition (SDS-PAGE analysis).

  • Endotoxin level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Form

    Lyophilized

• Background

  • Synonyms

    CD152

    Uniprot ID

    NCBI Reference Sequence: NP_001003106.1

  • Sequence Note

    Lys36-Asp161

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant Canine CTLA-4 Protein.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.