Human ACE2, Fc Tag, HEK293

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Catalog Number

LDG009PHM

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression system

    HEK293

  • Affinity Tag

    Mouse IgG2b Fc Tag (C-term)

    Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >98% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 109.67 kDa.
    The protein migrates as 120-170 kDa under reducing condition (SDS-PAGE analysis).

  • Activity

    Measured by its ability to bind SARS-CoV2 spike protein(RBD) in functional ELISA. Immobilized Recombinant SARS-CoV2 spike protein(RBD) at 2 μg/mL (100 μL/well) can bind Recombinant Human ACE2 Protein.

    Endotoxin level

    <0.1 EU per 1 μg of the protein by the LAL method.

  • Form

    Lyophilized

• Background

  • Background

    Angiotensin-Converting Enzyme 2 (ACE2) has a function as an enzyme that hydrolysis the angiotensin II into angiotensin which do the effect of anti-oxidation and anti-inflammatory in cardiovascular system through the inhibition of MAPK pathway and TGF β signaling pathway. ACE2 is highly expression in intestines, kidney, and heart. It is also fonud highy expression in patients with lung cancer.

    Synonyms

    Angiotensin-converting enzyme 2, Angiotensin-converting enzyme homolog, ACEH, Angiotensin-converting enzyme-related carboxypeptidase, ACE-related carboxypeptidase, Metalloprotease MPROT15

  • Uniprot ID

    Q9BYF1

    Sequence Note

    Gln18-Ser740

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration of 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  HPLC analysis of recombinant Human ACE2, Fc Tag, HEK293.
  The purity of Human ACE2 Protein is greater than 95% as determined by RP-HPLC.

  SDS-PAGE analysis of recombinant human ACE2.

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• Review

  

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• Publication

  1. Cheng YL et al. Frontiers in immunology. 2022; 13:941923.
  2. Lai YC et al. Frontiers in immunology. 2022; 13:868724.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.

最後更新：2026.09.14