Human NF-L, His-SUMO Tag, E. coli

Catalog Number

LDG179PHE

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression system

    Escherichia coli

  • Affinity Tag

    His-SUMO Tag (N-term)

    Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 73.91 kDa.
    The protein migrates as 75 kDa under reducing condition (SDS-PAGE analysis).

  • Endotoxin level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Form

    Lyophilized

• Background

  • Background

    Neurofilaments (NF) are assembled as heteropolymers, found exclusively in neurons, and serve as axonal scaffolding. They are composed of three subunits, including NF-L (68 kDa), NF-M (95 kDa), and NF-H (115 kDa), that are essential for axonal growth and maintenance. Elevated NF-L levels in serum and CSF (cerebrospinal fluid) have been correlated with axonal damage in Multiple Sclerosis patients, serving as a prognostic marker. In addition, plasma NF-L concentrations were highly significantly higher in patients with Alzheimer’s disease.

    Synonyms

    68 kDa neurofilament protein, Neurofilament triplet L protein

  • Uniprot ID

    # P07196

    Sequence Note

    Ser2-Asp543

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant human NF-L.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.