Human TL1A, His Tag, E. coli

Catalog Number

LDG126PHE

Datasheet

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• Specifications

  • Species of Origin

    Human

    Expression system

    Escherichia coli

  • Affinity Tag

    His Tag (C-term)

    Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 8.0.

  • Purity

    >98% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 22.95 kDa.
    The protein migrates as 24 kDa under reducing condition (SDS-PAGE analysis).

  • Activity

    Measure by its ability to induce TF-1 cells proliferation. The ED₅₀ for this effect is <0.2 ng/mL.

    Endotoxin level

    <0.1 EU per 1 μg of the protein by the LAL method.

  • Form

    Lyophilized

• Background

  • Background

    TL1A also known as VEGI and TNFSF15, which belongs to TNF ligand superfamily. TL1A is a 28 kDa type II membrane protein containing 251 residues that predominantly expressed in endothelial cells. TL1A is able to promote NFκB activation in cells by interacting with DR3. Besides, TL1A can also induces cell apoptosis through activating caspases. Additionally, the responsiveness of IL-2 from activated T cells has been shown to induce by TL1A treatment.

    Synonyms

    TNF-Like Ligand 1A, TL1A, Vascular endothelial cell growth inhibitor, Tumor necrosis factor ligand superfamily member 15

  • Uniprot ID

    #O95150

    Sequence Note

    Gln58-Leu251

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 2 weeks under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant human TL1A.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.