Mouse CAIX, His Tag, CHO

Catalog Number

LDG017PMM

Datasheet

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• Specifications

  • Species of Origin

    Mouse

    Expression system

    CHO

  • Affinity Tag

    His Tag (C-term)

    Buffer

    Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.

  • Purity

    >95% as determined by SDS-PAGE analysis.

    Molecular weight

    The protein has a calculated MW of 39.66 kDa.
    The protein migrates as 42 kDa under reducing condition (SDS-PAGE analysis).

  • Endotoxin level

    <0.1 EU per 1 μg of the protein by the LAL method.

    Form

    Lyophilized

• Background

  • Background

    CAIX (Carbonic Anhydrase IX) protein, a transmembrane enzyme, is overexpressed in various solid tumors, including renal cell carcinoma. It catalyzes the reversible hydration of carbon dioxide to bicarbonate ions and protons, playing a crucial role in pH regulation and acid-base balance within the tumor microenvironment. CAIX facilitates tumor cell survival, migration, and invasion by maintaining an acidic extracellular pH and promoting angiogenesis. Its selective expression in tumor tissues makes CAIX an attractive target for cancer therapy. Inhibiting CAIX activity disrupts tumor growth and metastasis, highlighting its significance as a diagnostic and therapeutic biomarker in oncology.

    Synonyms

    Carbonate dehydratase IX, Carbonic anhydrase IX (CA-IX; CAIX)), Membrane antigen MN homolog

  • Uniprot ID

    Q8VHB5

    Sequence Note

    Met1-Asp390

• Instruction

  • Reconstitution

    It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 0.2 mg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

    Shipping

    The product is shipped with polar packs. Upon receipt, store it immediately at -20°C or lower for long term storage.

  • Stability & Storage

    This product is stable after storage at:

    • -20°C for 12 months in lyophilized state from date of receipt.
    • -20°C or -80°C for 1 month under sterile conditions after reconstitution.

    Avoid repeated freeze/thaw cycles.

• Image

  SDS-PAGE analysis of recombinant mouse CAIX.

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• Datasheet & Documents

  Datasheet

  MSDS

  Manual

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Disclaimer：For Research Use or Further Manufacturing Only.