Chronic Kidney Disease

Catalog Number：

LGM-18002 (EN)

Package：

Package：96 T (8 x 12 strips)

Description：

Description：Indoxyl Sulfate (IS) is a protein-bound uremic toxin (PBUT) that is produced by the intestinal flora decomposing tryptophan in food and is normally excreted through the kidneys. However, in patients with CKD, the impaired renal function (decreased GFR) leads to the accumulation of IS, resulting in elevated concentrations in vivo. The accumulation of these uremic toxins can cause toxicity to renal tubules and renal tissues. This toxicity is manifested through various mechanisms, including the induction of oxidative stress and reduction in antioxidant capacity, leading to tubulointerstitial damage. Additionally, it can result in apoptosis and necrosis of renal tubular cells and the production of fibrosis-related factors, further contributing to overall renal structural damage and loss of renal function. Furthermore, it promotes the disease process of CKD, eventually leading to end-stage renal disease (ESRD) where hemodialysis and other treatments become necessary. In patients with CKD, the serum concentration of IS is negatively correlated with the GFR and positively correlated with mortality. IS may also have adverse effects on other organs or systems, including, but not limited to, renal bone disease, sarcopenia, neurodegenerative diseases, and cardiovascular diseases such as atherosclerosis and arterial sclerosis.

Catalog Number：

LDG00011E

Package：

Package：96 T (8 x 12 strips) / Customized package

Description：

Description：Matrix metalloproteinase7 (MMP7), also known as matrilysin, is a member of the matrix metalloproteinase family involved in extracellular matrix remodeling. MMP7 is synthesized as an inactive proenzyme and subsequently processed into its mature, active form, both of which are associated with tissue remodeling, inflammation, and cancer progression. Accurate and sensitive detection of total MMP7, including both pro and mature forms, is important for basic research and disease-related studies. Leadgene® Total MMP7 ELISA Kit is an enzyme-linked immunosorbent assay (ELISA) for the quantitative detection of total MMP7 levels in sample solution. The Total MMP7 ELISA Kit is for research use only (RUO). Not suitable for use in diagnostic or therapeutic procedures.

Conjugation：

Conjugation：HRP

Catalog Number：

LDG00010E

Package：

Package：96 T (8 x 12 strips) / Customized package

Description：

Description：Matrix metalloproteinase 7 (MMP7), also known as matrilysin, is a member of the matrix metalloproteinase family involved in extracellular matrix remodeling. The mature (active) form of MMP7 plays a critical role in tissue remodeling, inflammation, and tumor invasion, and has been associated with various pathological conditions, including cancer and inflammatory diseases. Accurate and sensitive detection of mature MMP-7 is important for basic research and disease-related studies. Leadgene® Mature MMP7 ELISA Kit is an enzyme-linked immunosorbent assay (ELISA) for the quantitative detection of mature MMP7 levels in sample solution. The Mature MMP7 ELISA Kit is for research use only (RUO). Not suitable for use in diagnostic or therapeutic procedures.

Conjugation：

Conjugation：HRP

Catalog Number：

LDG00004E

Package：

Package：96 T (8 x 12 strips) / Customized package

Description：

Description：The receptor for advanced glycation end products (RAGE) is a multiligand cell surface receptor belonging to the immunoglobulin superfamily. RAGE is involved in various cellular processes, including inflammatory responses, oxidative stress regulation, and signal transduction, and has been associated with multiple pathological conditions such as cancer, cardiovascular diseases, and chronic inflammatory disorders. Reliable detection and quantification of RAGE are important for basic research and disease-related studies. Leadgene® RAGE ELISA Kit is an enzyme-linked immunosorbent assay (ELISA) for the quantitative detection of RAGE levels in sample solution. The RAGE ELISA Kit is for research use only (RUO). Not suitable for use in diagnostic or therapeutic procedures.

Conjugation：

Conjugation：HRP